сендвич транспортер

ATP Binding to the Motor Domain from an ABC Transporter…

an ABC Transporter Drives Formation of a Nucleotide Sandwich Dimer porters and most eukaryotic transporters, they are fused together in a single polypeptide.

Culture perioddependent changes in the uptake of…

Jun 14, 2011 ... Culture perioddependent changes in the uptake of transporter substrates in sandwichcultured rat and human hepatocytes. Kotani N(1)...

Functional expression and regulation of drug…

canalicular drug transporter mRNA expression in short time (4h)cultured ... Drug transporters; primary hepatocytes; mouse; monolayer; sandwich; regulation.

Hepatocellular Disposition and Transporter…

Mar 24, 2016 ... Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in SandwichCultured Human Hepatocytes. Lu Y(1)...

Regulation of MRP2/ABCC2 and BSEP/ABCB11 Expression in…

Oct 8, 2010 ... In the present study the sandwich cultured (SC) human and rat hepatocytes were used to investigate the transporter regulation and to further...

BioreclamationIVT and Qualyst Partner to Market…

Jun 22, 2017 ... In sandwich culture, the intracellular concentrations in Transporter Certified hepatocytes reflect physiologic conditions because the hepatocytes...

Mechanistic Pharmacokinetic Modeling for the ... …

Mechanistic Pharmacokinetic Modeling for the Prediction of. TransporterMediated Disposition in Humans from Sandwich. Culture Human Hepatocyte Data. □S.

SandwichCultured Hepatocytes: An In Vitro Model to ... NCBI …

Sandwichcultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to study hepatobiliary drug transport, species differences in drug transport,...

NGlycosylation of ABC transporters is associated with…

Oct 9, 2017 ... Hepatobiliary elimination via canalicular efflux transport proteins plays a key role in the clearance of endo and xenobiotics. Correct membrane...

Sandwichcultured hepatocytes: an in vitro model to evaluate…

Sandwichcultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to study hepatobiliary drug transport, species differences in drug transport,...

SandwichCultured Hepatocytes as a Tool to Study Drug…

Sandwichcultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile...

RCSB PDB 1L2T: Dimeric Structure of MJ0796, a Bacterial ABC…

1L2T: ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.

Interaction between HIV protease inhibitors (PIs) and hepatic…

Mar 4, 2013 ... Interaction between HIV protease inhibitors (PIs) and hepatic transporters in sandwich cultured human hepatocytes: implication for PIbased...

Screening Drug Transporter Proteins Discovery On…

Cambridge Healthtech Institute's Inaugural conference on Screening Drug Transporter Proteins will cover the latest in the use of 2D and 3D in vitro systems and...

Basolateral Efflux Transporters: A Potentially…

Nov 11, 2016 ... The hepatocyte adaptive response has been postulated to play a protective role in cholestatic disease states, including primary biliary cirrhosis...

An In Vitro Assay to Assess TransporterBased…

Feb 1, 2010 ... Transporters involved in the hepatic uptake of drugs and bile acids from the ... Most in vitro transporter assays using suspended hepatocytes,...

primary hepatocytes UNC Chapel Hill

Jan 31, 2008 ... models with which the study of drug metabolism and transporter interactions is ... metabolizing enzymes and transport proteins, organized in a...

Imaging Bile Canaliculi PerkinElmer

for studying efflux transporter function. Sandwichcultured hepatocytes also are utilized as an in vitro tool to study hepatobiliary drug transport and hepatotoxicity.

HepatoPac® BCLEAR® Transporter Kit Hepregen

Hepregen and Qualyst provide bestinclass kit for transporter applications.

Characterization of Arsenic Hepatobiliary Transport…

Mar 9, 2015 ... In rats, the related canalicular transporter Mrp2/Abcc2 is required for ... suggest arsenic basolateral transport prevails over biliary excretion and...

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Expression and hepatobiliary transport…

Sep 5, 2008 ... In the sandwichcultured hepatocytes, ENTs were the major contributors to the transport of thymidine (hENT1, 63%; hENT2, 23%) or guanosine...

Sandwichcultured rat hepatocytes as an in vitro model to study…

Abstract. At present, it has not been systematically evaluated whether the functional alterations induced by cholestatic compounds in canalicular transporters...

Quantitative Expression Profile of Hepatobiliary…

Jun 22, 2009 ... Following the sandwich culture, the species difference of hepatobiliary transporter protein between human and rat at day 5 post SC was...

Transporter Certified™ Hepatocytes Qualyst…

drug transporters in in vitro transfected systems are difficult to translate into reliable, in vivo knowledge. An integrated in vitro system, such as sandwichcultured...

Sandwichcultured hepatocyte Assay Service Categories Solvo…

Sandwichcultured hepatocytes are a common in vitro model used to investigate hepatic transportermediated efflux and uptake of test compounds, as well as...

Induction of Transporter Expression and Modulation of…

Transporterrelated drug interactions are emerging as an important consideration in the clearance of drugs. In particular, hepatic clearance is important due to...

Biliary efflux transporters involved in the clearance of…

This study was designed to elucidate, which transporters take part in the biliary clearance of rosuvastatin using sandwichcultured primary rat hepatocytes.

Evaluation of the Endothelin Receptor Antagonists Ambrisentan…

Jan 30, 2014 ... Background Inhibition of the transportermediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with...